Positive ANA? What could I have?

Emma E Asked: Positive ANA? What could I have?

I ran my ANA twice, (one several months after the other, neither of which I was sick during), and both times it came up positive.1 to 160 speckled
I have cold hands and feet and mylimbs fall asleep very easily, and i have cataplexy-like symptoms.But they don't change color at all.
They ran a lupus panel, negative.
I don't have trouble walking and moving, although I always hurt everywhere
I crack my joints a lot, I go to a chiropractor, I feel it helps my circulation
I always have a headache, and sometimes it gets much worse. But I've never had a migraine.
I went to the neurologist and they ran an eeg, nothing found.
My bloods are fine, I'm not anemic or have diabetes or anything….Nothing but the positive ANA
I see a rheumatologist again soon, hope to find results….but in the meantime I'd love some possibilities…..if anyone knows….so please help?
what could I have? What are the symptoms of that? suggestions?


pecola princepessa Answered:
Mononucleosis is one type of infection that has been associated with the development of antinuclear antibodies. Some blood pressure lowering drugs and certain anti-seizure medications may trigger antinuclear antibody formation as well.
having a positive ANA does not necessarily mean you have a disease

Wabby Answered:
The ANA test is a very flawed test. Many of the healthy population will test positive and have nothing wrong.

The test is measured in titers, anything under 1:40 is considered negative on paper. So the results go 1:40, 1:80, 1:160, 1:320, 1:640, 1:1280 and continues to double. My rheumatologist said that an ANA under 1:640 would be considered negative and non suggestive of an autoimmune disease.

One study studied 485 healthy volunteer blood donors and found that 20% of the women and 7% of the men had a positive ANA result. Of women over 40 years of age, 31% were ANA-positive.

Another study found an ANA titer of at least 1:640 in 15% of healthy women younger than 40 years and 24% of women age 40 or older.

In another study of healthy adults (age 20 to 60 years), found that 31.7% had a positive ANA result at a 1:40 dilution, 13.3% at a 1:80 dilution, 5% at a 1:160 dilution, and 3.3% at a 1:320 dilution.

Another study looked at 1,010 ANA results in a hospital. Fifteen percent of all patients and 30% of patients older than 65 years had a positive ANA titer of 1:40 or greater, but the positive predictive value for rheumatic disease was low. The false-positive rate for any rheumatic disease was 72% in patients 65 years old or younger, and 90% in patients older than 65 years. Even ANAs that were positive at a titer of 1:320 or greater were more likely to be falsely positive (55%) than indicative of any rheumatic disease (45%).

So studies have found, 20% of woman have a positive ANA but nothing wrong. 5% of healthy people have a positive ANA at your level. And 72% of all positive ANAs in under 65 year olds are positive for no reason.

But if you're in the 28% of people with a positive ANA and have a rheumatological condition you may have…..

Lupus erythematosus
Sjgren's syndrome
Rheumatoid arthritis
Autoimmune hepatitis
Polymyositis & dermatomyositis
Addison disease
Idiopathic thrombocytopenic purpura
Autoimmune hemolytic anemia
Type I diabetes mellitus
Mixed connective tissue disorder

It also depends on what pattern your ANA is as it can point towards a specific condition, for example…

-Rim Pattern-
Systemic Lupus Erythematosus

-Homogenous Pattern-
Systemic Lupus Erythematosus (Very specific)

-Speckled Pattern-
Most common, least specific
Systemic Lupus Erythematosus
Mixed Connective Tissue Disease
Sjogren's Syndrome

-Nucleolar Pattern-
CREST syndrome

-Centromere Pattern-
CREST syndrome

But no blood test on its own is enough evidence for anything. You need to have symptoms and meet the other criteria.

It's a good thing you're seeing a rheumatologist. They'll be able to work out what's going on and whether your ANA is positive because you have an autoimmune disease.


Kendall Answered:
Positive ANA indicates a autoimmune disease. A rheumotologist should be helpful. We can not really diagnose you, but a rheumotologist should be able to give you a diagnosis.

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